Safpep Anti-Ulcerants
Omeprazole is a proton-pump inhibitor, used to treat gastric acid-related disorders.
Safpep Omeprazole 40mg
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Adults
Indication
Dose
Duration
Treatment of Duodenal Ulcers
20 mg Once daily
2 weeks. Some patients may require an additional 2 weeks
Prevention of relapse of duodenal ulcers
20 mg Once daily
As directed by physician
Treatment of Gastric ulcers
20mg Once daily
4 weeks. If not healed further 4 weeks.
Prevention of relapse of Gastric ulcers
20 mg Once daily or 40mg Once daily
As directed by physician
H. pylori Eradication in Peptic Ulcer Disease
Omeprazole 20 mg BID
Amoxicillin 1000 mg BID
Clarithromycin 500 mg BID
1 week
If the patient is still H. pylori positive, therapy may be repeated
Omeprazole 20 mg BID
Clarithromycin 250 or 500 mg BID
Metronidazole 400 mg BID
1 week
If the patient is still H. pylori positive, therapy may be repeated.
Omeprazole 40mg OD
Amoxicillin 500 mg TID
Metronidazole 400mg TID
1 week
If the patient is still H. pylori positive, therapy may be repeated.
Treatment of NSAID-associated gastric and duodenal ulcers
20 mg Once daily
As directed by physician
Prevention of NSAID-associated gastric and duodenal ulcers in patients at risk
20 mg Once daily
As directed by physician
Treatment of reflux oesophagitis
Severe oesophagitis
20 mg-40mg Once daily
4 to 8 weeks
Long-term management of patients with healed reflux oesophagitis
20-40 mg once daily
As directed by physician
Treatment of symptomatic gastro-oesophageal reflux disease
20 mg once daily
As directed by physician
Treatment of Zollinger-Ellison syndrome
60 mg once daily
As long as clinically indicated.
Paediatric Patients
Children over 1 year of age and ≥ 10 kg
Indication
Dose
Duration
Treatment of reflux oesophagitis
≥ 1 year of age 10-20kg weight
Omeprazole 10mg OD. Can be increased to 20mg OD if needed
4 to 8 weeks
≥ 2 years of age > 20kg
Omeprazole 10mg OD. Can be increased to 20mg OD if needed
Symptomatic treatment of heartburn and acid regurgitation in GERD:
≥ 1 year of age 10-20kg weight
Omeprazole 10mg OD. Can be increased to 20mg OD if needed
2 to 4 weeks If symptom control has not been achieved the patient should be investigated further.
≥ 2 years of age > 20kg
Omeprazole 10mg OD. Can be increased to 20mg OD if needed
Children and adolescents over 4 years of age
Treatment of duodenal ulcer caused by H. pylori
15-30kg
Omeprazole 10mg BID + Amoxicillin 25mg/kg body weight BID + clarithromycin 7.5mg/kg body weight BID
1 week
31-40kg
Omeprazole 20mg BID + Amoxicillin 250mg BID + clarithromycin 7.5mg/kg body weight BID
>40kg
Omeprazole 20mg BID + Amoxicillin 1000mg BID + clarithromycin 500mg BID
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- Hypersensitivity to omeprazole, substituted benzimidazoles or to any of the excipients.
- Omeprazole like other proton pump inhibitors (PPIs) must not be used concomitantly with nelfinavir.